Name: DNA Methylation Plus Test
Brand: GetTested
SKU: DNAMP
Price: 249.99 USD
Availability: InStock
Rating: NaN (100 reviews)

CUBN (Cubilin) is a multifunctional receptor protein involved in the absorption and transport of key nutrients, including vitamin B12 and various proteins such as albumin. It plays a vital role in the kidneys and intestines, where it helps reabsorb filtered proteins and supports nutrient uptake. In the kidney, CUBN works alongside megalin to maintain protein balance, while in the gut, it is essential for the efficient transport of vitamin B12, supporting normal metabolism and cellular function.

CUBN

MTHFR (Methylenetetrahydrofolate Reductase): MTHFR is an enzyme that plays a key role in folate metabolism and the regulation of homocysteine levels. It converts 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate, allowing the remethylation of homocysteine to methionine — a precursor to S-adenosylmethionine (SAM), the body's main methyl donor. Variants in the MTHFR gene, such as C677T and A1298C, can influence enzyme activity, potentially changing folate metabolism, increasing homocysteine levels, and affecting methylation-dependent processes like DNA methylation and neurotransmitter synthesis.

MTHFR

FUT2 (Fucosyltransferase 2) is a gene that encodes an enzyme involved in synthesizing histo-blood group antigens and determining secretor status. It catalyzes the transfer of fucose to specific molecules, enabling the production of glycoproteins and glycolipids found in bodily fluids and epithelial tissues. FUT2 activity affects the expression of the H antigen — a key precursor to ABO blood group antigens — and plays a crucial role in whether these antigens are present in secretions like saliva.

FUT2

MTR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase): MTR is a key enzyme involved in the remethylation pathway of homocysteine metabolism. It catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate (5-MTHF) to homocysteine, producing methionine and tetrahydrofolate (THF). Methionine serves as a precursor for S-adenosylmethionine (SAM), a universal methyl donor essential for various methylation reactions in the body, including DNA methylation, neurotransmitter synthesis, and histone modification. Proper MTR activity is crucial for maintaining normal homocysteine levels and supporting cellular methylation processes. Dysregulation of MTR, often caused by genetic mutations or deficiencies, can disrupt these critical functions.

The TCN2 gene encodes transcobalamin II, a protein responsible for transporting vitamin B12 (cobalamin) from the bloodstream into cells. Once vitamin B12 is absorbed in the gut, it must bind to transcobalamin to be delivered to tissues where it is used for DNA synthesis, red blood cell production, and neurological function. Genetic variations in TCN2 can decrease the efficiency of B12 transport, potentially leading to functional B12 deficiency even when blood levels appear normal. This may contribute to symptoms such as fatigue, cognitive changes, or elevated homocysteine.

TCN2

FOLH1 (Folate Hydrolase 1), also known as Prostate-Specific Membrane Antigen (PSMA), is a gene involved in folate metabolism and the activation of folate for DNA synthesis and repair. It plays a key role in cell growth and division. FOLH1 is notably expressed in prostate cancer cells, making it a valuable target for cancer diagnosis and therapy.

FOLH1

The MTHFS gene encodes methenyltetrahydrofolate synthetase, an enzyme involved in folate metabolism. It plays a vital role in maintaining the pool of active folate derivatives used for methylation, DNA synthesis, and neurotransmitter production. MTHFS regulates the conversion of various folate forms and helps keep the balance of one-carbon units essential for cellular function. Variants in this gene may disrupt folate recycling, potentially affecting methylation pathways and contributing to problems such as impaired detoxification, fatigue, or mood imbalance.

MTHFS

DHFR (Dihydrofolate Reductase) is an enzyme that plays a crucial role in DNA synthesis and repair. It catalyzes the conversion of dihydrofolate to tetrahydrofolate, an essential cofactor for producing purines, thymidylate, and certain amino acids. This process is vital for cell growth and division, making DHFR a key target in cancer treatment, where inhibitors such as methotrexate block its activity to stop rapidly dividing cells.

DHFR

The TYMS gene encodes thymidylate synthase, a crucial enzyme involved in the production of thymidine, one of the four nucleotides necessary for DNA replication and repair. This enzyme depends on active folate (5,10-methylene-THF) to function effectively, closely linking TYMS to folate metabolism. Variants in the TYMS gene can influence folate availability at the cellular level and may affect how the body responds to folate or folate-based treatments. These changes can contribute to disrupted DNA synthesis, increased risk of certain diseases, or varied responses to chemotherapy or supplementation.

TYMS

MTHFD1 (Methylenetetrahydrofolate Dehydrogenase 1): MTHFD1 is a key enzyme in the folate metabolism pathway, catalyzing the conversion of tetrahydrofolate (THF) derivatives into forms used for the synthesis of DNA, RNA, and amino acids. It plays a vital role in one-carbon metabolism, influencing cellular methylation reactions and nucleotide production. Mutations or dysregulation of MTHFD1 can disrupt folate metabolism and are associated with an increased risk of congenital defects, cardiovascular diseases, and cancer.

MTHFD1

MTRR (Methionine Synthase Reductase): MTRR is an enzyme that plays a crucial role in regenerating methylcobalamin, supporting the continuous function of MTR in homocysteine metabolism. It is essential for maintaining proper methionine levels and normal DNA synthesis. Mutations in MTRR are associated with homocystinuria, which can lead to developmental and neurological complications. Understanding MTRR function provides insights into potential therapies for genetic disorders.

MTRR

The MTHFD1L gene encodes a mitochondrial enzyme involved in the folate cycle and one-carbon metabolism, specifically in converting formate to 10-formyl-THF. This process supports purine synthesis and methylation reactions, which are essential for DNA and RNA production and cellular repair. Genetic variations in MTHFD1L can impact mitochondrial folate metabolism and have been linked to a higher risk of neural tube defects, cardiovascular problems, and impaired methylation. It functions complementarily to the cytosolic MTHFD1 gene but operates within the mitochondria.

MTHFD1L

SHMT1 (Serine Hydroxymethyltransferase 1): SHMT1 is an enzyme that catalyzes the conversion of serine and tetrahydrofolate into glycine and methylenetetrahydrofolate. This process is essential for nucleotide synthesis and methylation reactions, which support DNA replication and repair. SHMT1 plays a key role in cell growth and genetic stability, and its activity in folate metabolism is linked to cancer risk and neurological disorders.

SHMT1

What is measured in the Folate Cycle?

GNMT (Glycine N-Methyltransferase) is a key enzyme involved in methionine metabolism and liver detoxification. It helps regulate homocysteine levels by converting excess methionine into sarcosine, preventing harmful methionine buildup and supporting liver health. Dysfunction of GNMT is linked to liver conditions such as fatty liver disease and liver cancer. Ongoing research emphasizes GNMT’s protective role against liver toxicity and its potential as a marker for evaluating liver health.

GNMT

AHCY: Encodes the enzyme adenosylhomocysteinase, which plays a key role in converting S-adenosylhomocysteine to homocysteine, an essential step in the body's methylation processes and detoxification.

AHCY

BHMT (Betaine-Homocysteine S-Methyltransferase): BHMT is an enzyme that indicates the body’s capacity to metabolize homocysteine, a process crucial for cardiovascular and neurological health. BHMT catalyzes the conversion of homocysteine into methionine using betaine as a methyl donor. Dysregulation of BHMT can result in elevated homocysteine levels, which are linked to cardiovascular disease and other health issues.

BHMT

COMT (Catechol-O-Methyltransferase): COMT is an enzyme that plays a key role in the metabolism of catecholamines, including dopamine, epinephrine, and norepinephrine. It is important for regulating neurotransmitter levels in the brain and is linked to psychiatric disorders such as schizophrenia. COMT also contributes to the body’s pain response and has been studied in relation to pain sensitivity and various mental health conditions.

COMT

MAT1A (Methionine Adenosyltransferase I, Alpha) is an enzyme that produces S-adenosylmethionine (SAMe), the body’s main methyl donor for essential metabolic processes. It plays a key role in methionine metabolism, affecting gene regulation, cell growth, and detoxification. Reduced MAT1A activity is associated with liver conditions such as cirrhosis and hepatocellular carcinoma.

MAT1A

CHDH (Choline Dehydrogenase) is a crucial enzyme involved in choline metabolism, converting choline into betaine. This process supports the production of acetylcholine, a key neurotransmitter, and helps regulate homocysteine levels, which is vital for cardiovascular health. CHDH activity affects choline availability, impacting liver function, brain development, and nervous system health. Researching CHDH can provide valuable insights into nutritional requirements and interventions for metabolic disorders.

CHDH

PEMT (Phosphatidylethanolamine N-Methyltransferase): PEMT is an enzyme that converts phosphatidylethanolamine into phosphatidylcholine in the liver, a crucial step for maintaining cell membrane integrity and facilitating VLDL secretion. Its activity influences liver function, fat metabolism, and choline requirements, with dysregulation associated with increased risk of liver and cardiovascular diseases.

PEMT

DNMT3B (DNA Methyltransferase 3 Beta) is a gene that encodes an enzyme involved in DNA methylation—an important epigenetic mechanism that regulates gene expression. DNMT3B plays a crucial role in development and has been associated with conditions such as ICF syndrome and various types of cancer.

DNMT3B

What is measured in the Methionine Cycle?

CBS (Cystathionine beta-synthase): CBS is an enzyme crucial for sulfur metabolism, playing a key role in converting homocysteine into cysteine. This process supports the production of glutathione, a vital antioxidant that protects cells from oxidative stress. CBS also participates in the transsulfuration pathway, which regulates sulfur-containing amino acids and hydrogen sulfide, a signaling molecule involved in various physiological functions. Proper CBS activity is essential for maintaining cellular redox balance, vascular function, and neurotransmitter regulation. Dysregulation of CBS is associated with metabolic disorders such as homocystinuria and cardiovascular diseases.

The PDXK gene codes for the enzyme pyridoxal kinase, which is crucial for converting vitamin B6 into its active form, pyridoxal-5′-phosphate (PLP). PLP acts as a coenzyme in over 100 enzymatic processes, many of which play roles in amino acid metabolism, neurotransmitter production, and energy generation. Variations in the PDXK gene can disrupt this conversion, potentially causing a functional vitamin B6 deficiency even when vitamin B6 intake is adequate. Altered PLP levels have been associated with neurological symptoms, fatigue, and mood changes.

PDXK

What is measured in the Transsulfuration?

Our DNA Methylation test is a home testing kit. After placing your order, we will send you a kit containing everything you need to collect your saliva sample. Then, simply send your sample back to us using the prepaid envelope.

How is the DNA Methylation Plus Test performed?

This test is designed for individuals seeking a deeper understanding of their genetic predispositions related to mood, energy, detoxification, hormonal balance, and overall health. It can be especially beneficial for those experiencing chronic fatigue, mood swings, or with a family history of cardiovascular or neurological conditions.

Who should consider taking this test?

Once we receive your sample, you can expect to receive your results within 6-8 weeks.

How quickly will I get my results?

The test can be taken at any time of day.

When should I take the test?

We use genotyping, a reliable method that looks at key points in your DNA called SNPs.

What testing method does your DNA test use?

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The DNA Methylation Plus test provides a detailed insight into your body's methylation processes by analyzing key genes. Methylation is a crucial biological process that influences gene expression, DNA repair, and detoxification pathways. It plays a significant role in various bodily functions and can impact everything from energy levels to mood and immune function. A DNA methylation test can be particularly beneficial for individuals interested in understanding their body's ability to process and detoxify, those experiencing health issues without clear causes, or anyone looking to optimize their overall health.
The test examines genes such as BHMT, MTHFR, COMT, AHCY, among others, providing insights into how your body regulates methylation. This process is essential for cell health and can influence risk factors for certain conditions, nutrient requirements, and the body's response to environmental toxins.
Genes in the DNA Methylation Test
Folate Cycle
These genes are involved in folate metabolism, a process crucial for DNA synthesis, repair, and methylation.

DHFR – Catalyzes the conversion of dihydrofolate to tetrahydrofolate (THF), essential for DNA synthesis and cell growth.
FOLH1 – Influences the conversion of folate to its active form, critical for methylation processes.
MTHFR – A key gene in the folate cycle that converts 5,10-methylene-THF to 5-methyl-THF, the form of folate required for methionine synthesis.
MTHFD1 – Supports the production of formate and tetrahydrofolate, impacting DNA methylation and synthesis.
MTHFD1L – Affects mitochondrial folate metabolism and may play a role in epigenetic regulation.
MTHFS – Catalyzes the conversion of formyl-THF to methenyltetrahydrofolate, influencing folate metabolism and methylation.
SHMT1 – Involved in the conversion of serine to glycine, contributing to folate metabolism, DNA synthesis, and methylation.

Methionine Cycle
This cycle is essential for converting homocysteine to methionine and producing S-adenosylmethionine (SAM-e), one of the body's most important methyl donors.

AHCY – Catalyzes the breakdown of S-adenosylhomocysteine (SAH) to homocysteine, a key process for methylation balance.
BHMT – Helps recycle homocysteine into methionine by using betaine as a methyl donor.
COMT – Responsible for the methylation and breakdown of catecholamines (e.g., dopamine and adrenaline), influencing stress response and mood.
GNMT – Regulates S-adenosylmethionine (SAM-e) levels and contributes to methylation balance.
MAT1A – Encodes methionine adenosyltransferase, which produces SAM-e, an essential molecule for methylation of DNA, proteins, and lipids.
MTR – Encodes methionine synthase, which converts homocysteine into methionine with the help of vitamin B12.
MTRR – Regenerates methylcobalamin, ensuring the continuous function of methionine synthase (MTR).
PEMT – Essential for the production of phosphatidylcholine, supporting cell membrane stability and methylation processes by providing choline.
TCN2 – Encodes transcobalamin II, a transport protein that delivers vitamin B12 to cells, crucial for methylation.

Transsulfuration & Related Processes
This section includes genes involved in converting homocysteine into sulfur-containing compounds and genes related to methylation and antioxidant defense.

CBS – Regulates the breakdown of homocysteine via the transsulfuration pathway, influencing detoxification and antioxidant defense.
CHDH – Encodes choline dehydrogenase, which converts choline to betaine, an essential cofactor for methylation and homocysteine metabolism.
CUBN – Affects vitamin B12 absorption, crucial for methylation and detoxification processes.
DNMT3B – Encodes an enzyme involved in DNA methylation and epigenetic regulation.
FUT2 – Influences gut microbiota composition and may play a role in vitamin B12 metabolism.
PDXK – Activates vitamin B6, an important cofactor in enzymatic reactions related to methylation and homocysteine metabolism.

How the Test Works
The DNA Methylation test is performed using a simple saliva sample collected at home. The process is straightforward:

Order the Test: Receive your DNA Methylation test kit delivered directly to your home.
Collect Your Sample: Follow the easy-to-use instructions to collect your saliva sample.
Send it Back: Use the prepaid return envelope to send your sample to our laboratory.
Receive Your Results: Within 6-8 weeks, you will get a detailed digital report outlining your methylation pathways along with personalized recommendations.

Why Test for DNA Methylation?
Methylation affects numerous bodily functions and can be a key factor in overall well-being. Understanding your methylation status can help you make informed decisions about your diet, lifestyle, and healthcare, potentially uncovering hidden health issues or optimizing your health strategy. This test is ideal for individuals who:

Are curious about their genetic health.
Want to optimize their diet and lifestyle based on their genetics.
Experience unexplained health issues that may be related to methylation.

Sample & Data Privacy
Your DNA and sample material are destroyed after analysis. The sample is linked only to your unique test ID, ensuring complete anonymity. The laboratory does not have access to your identity, and we do not share results with third parties. You also have the option to delete your test results after receiving them.

The DNA Methylation Plus test provides a detailed insight into your body's methylation processes by analyzing key genes. Methylation is a crucial biological process that influences gene expression, DNA repair, and detoxification pathways. It plays a significant role in various bodily functions and can impact everything from energy levels to mood and immune function. A DNA methylation test can be particularly beneficial for individuals interested in understanding their body's ability to process and detoxify, those experiencing health issues without clear causes, or anyone looking to optimize their overall health. 
The test examines genes such as BHMT, MTHFR, COMT, AHCY, among others, providing insights into how your body regulates methylation. This process is essential for cell health and can influence risk factors for certain conditions, nutrient requirements, and the body's response to environmental toxins. 
Genes in the DNA Methylation Test 
Folate Cycle 
These genes are involved in folate metabolism, a process crucial for DNA synthesis, repair, and methylation.
DHFR – Catalyzes the conversion of dihydrofolate to tetrahydrofolate (THF), essential for DNA synthesis and cell growth. 
FOLH1 – Influences the conversion of folate to its active form, critical for methylation processes. 
MTHFR – A key gene in the folate cycle that converts 5,10-methylene-THF to 5-methyl-THF, the form of folate required for methionine synthesis. 
MTHFD1 – Supports the production of formate and tetrahydrofolate, impacting DNA methylation and synthesis. 
MTHFD1L – Affects mitochondrial folate metabolism and may play a role in epigenetic regulation. 
MTHFS – Catalyzes the conversion of formyl-THF to methenyltetrahydrofolate, influencing folate metabolism and methylation. 
SHMT1 – Involved in the conversion of serine to glycine, contributing to folate metabolism, DNA synthesis, and methylation.
Methionine Cycle 
This cycle is essential for converting homocysteine to methionine and producing S-adenosylmethionine (SAM-e), one of the body's most important methyl donors.
AHCY – Catalyzes the breakdown of S-adenosylhomocysteine (SAH) to homocysteine, a key process for methylation balance. 
BHMT – Helps recycle homocysteine into methionine by using betaine as a methyl donor. 
COMT – Responsible for the methylation and breakdown of catecholamines (e.g., dopamine and adrenaline), influencing stress response and mood. 
GNMT – Regulates S-adenosylmethionine (SAM-e) levels and contributes to methylation balance. 
MAT1A – Encodes methionine adenosyltransferase, which produces SAM-e, an essential molecule for methylation of DNA, proteins, and lipids. 
MTR – Encodes methionine synthase, which converts homocysteine into methionine with the help of vitamin B12. 
MTRR – Regenerates methylcobalamin, ensuring the continuous function of methionine synthase (MTR). 
PEMT – Essential for the production of phosphatidylcholine, supporting cell membrane stability and methylation processes by providing choline. 
TCN2 – Encodes transcobalamin II, a transport protein that delivers vitamin B12 to cells, crucial for methylation.
Transsulfuration & Related Processes 
This section includes genes involved in converting homocysteine into sulfur-containing compounds and genes related to methylation and antioxidant defense.
CBS – Regulates the breakdown of homocysteine via the transsulfuration pathway, influencing detoxification and antioxidant defense. 
CHDH – Encodes choline dehydrogenase, which converts choline to betaine, an essential cofactor for methylation and homocysteine metabolism. 
CUBN – Affects vitamin B12 absorption, crucial for methylation and detoxification processes. 
DNMT3B – Encodes an enzyme involved in DNA methylation and epigenetic regulation. 
FUT2 – Influences gut microbiota composition and may play a role in vitamin B12 metabolism. 
PDXK – Activates vitamin B6, an important cofactor in enzymatic reactions related to methylation and homocysteine metabolism.
How the Test Works 
The DNA Methylation test is performed using a simple saliva sample collected at home. The process is straightforward:
Order the Test: Receive your DNA Methylation test kit delivered directly to your home. 
Collect Your Sample: Follow the easy-to-use instructions to collect your saliva sample. 
Send it Back: Use the prepaid return envelope to send your sample to our laboratory. 
Receive Your Results: Within 6-8 weeks, you will get a detailed digital report outlining your methylation pathways along with personalized recommendations.
Why Test for DNA Methylation? 
Methylation affects numerous bodily functions and can be a key factor in overall well-being. Understanding your methylation status can help you make informed decisions about your diet, lifestyle, and healthcare, potentially uncovering hidden health issues or optimizing your health strategy. This test is ideal for individuals who:
Are curious about their genetic health. 
Want to optimize their diet and lifestyle based on their genetics. 
Experience unexplained health issues that may be related to methylation.
Sample & Data Privacy 
Your DNA and sample material are destroyed after analysis. The sample is linked only to your unique test ID, ensuring complete anonymity. The laboratory does not have access to your identity, and we do not share results with third parties. You also have the option to delete your test results after receiving them.

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DNA Methylation Plus Test

What is measured in the Folate Cycle?

What is measured in the Methionine Cycle?

What is measured in the Transsulfuration?

FAQ

Example report

Reviews

Trusted by over 100.000+ customers

Your Cart

DNA Methylation Plus Test

What is measured in the Folate Cycle?

What is measured in the Methionine Cycle?

What is measured in the Transsulfuration?

FAQ

Example report

Reviews

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Trusted by over 100.000+ customers

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