UBE2G1 (Ubiquitin-conjugating Enzyme E2 G1): UBE2G1 is part of the ubiquitin-conjugating enzyme family and plays a crucial role in the ubiquitin-proteasome system—a vital cellular pathway responsible for protein degradation and turnover. UBE2G1 specifically attaches ubiquitin molecules to target proteins, labeling them for degradation by the proteasome. This process is essential for regulating key cellular activities such as cell cycle progression, DNA repair, and signal transduction. The activity of UBE2G1 is tightly regulated and works in coordination with other components of the ubiquitin-proteasome system to maintain protein balance and ensure proper cellular function.